Receptors flex to remove neurotransmitter brake
نویسندگان
چکیده
منابع مشابه
Synaptic neurotransmitter-gated receptors.
Since the discovery of the major excitatory and inhibitory neurotransmitters and their receptors in the brain, many have deliberated over their likely structures and how these may relate to function. This was initially satisfied by the determination of the first amino acid sequences of the Cys-loop receptors that recognized acetylcholine, serotonin, GABA, and glycine, followed later by similar ...
متن کاملNeurotransmitter receptors on microglia
As the resident immune cells in the central nervous system, microglia have long been hypothesised to promote neuroinflammation and exacerbate neurotoxicity. However, this traditional view has undergone recent revision as evidence has accumulated that microglia exert beneficial and detrimental effects depending on activation status, polarisation phenotype and cellular context. A variety of neuro...
متن کاملAutoantibodies to Neurotransmitter Receptors and Ion Channels in Psychotic Disorders
Cell surface antibody–associated central nervous system disorders have emerged in the last decade as a novel field in neuroimmunology. It is now well known that patients with antibodies to ion channels such as N-methyl-D-aspartate receptor and voltage-gated potassium channel-complex manifest with prominent psychiatric symptoms and particularly psychosis early in the disease course. In this revi...
متن کاملNeurotransmitter Receptors in the Postsynaptic Neuron
Communication between adjacent neurons in the central nervous system occurs at specialized regions of the nerve cells termed the synapse. It is mediated by themovement of chemical mediators or neurotransmitters across a small gap that exists between the nerve cells. When a neuron is activated, it releases molecules of neurotransmitter from synaptic vesicles localized in the presynaptic terminal...
متن کاملEndocytosis of Neurotransmitter Receptors: Location Matters
Endocytosis of excitatory glutamate receptors from the postsynaptic plasma membrane plays a fundamental role in synaptic function and plasticity. In a recent study published in Neuron, Lu et al. (2007) describe protein interactions that link zones of receptor endocytosis directly to the postsynaptic scaffold and propose that local trafficking of receptors facilitated by these endocytic zones is...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2011
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1921iti3